Below is an example of how Lupine Medical partners with device manufacturers of products ranging from short-term skin-contacting devices to permanent, bloodstream contacting implants.

• Provide supporting materials and rationales for the fluid exchange model of drug dissolution for in-vitro elution and antimicrobial efficacy models
• Research applicable microbes that lead to the most infections for varying implanted devices
• Design in-vitro test plans around these microbes
• Determine minimum inhibitory concentration (MIC) of drug against these microbes
• Establish minimum bactericidal concentration (MBC) of drug against bacteria
• Oversee test method development, implementation, validation execution and reporting
• Demonstrate correlation between drug release and in-vitro antimicrobial efficacy
• Summarize reports and present data to FDA
• Execute in-vitro assay for the detection of activated platelets after device exposure
• Use flow-cytometry methods to identify blood markers for activation
• Identify and quantify platelets adhered to device surface using confocal microscopy
• Develop and validate customized blood compatibility testing